Given that Tampa is home to the sixth-largest casino venue in the entire world – the Seminole Hard Rock Hotel & Casino Tampa – you can be sure the city has more active gamblers than nearly anywhere else in the state. And this doesn’t take visitors and tourists into consideration. And given the fact that some 40% of US adults regularly participate in gambling of one kind or another, that means the city has over 100,000 active gamblers locally. With nearly 400,000 residents, Tampa is the third-largest city in Florida.